Age-specific immunity to rotavirus infection and the risk of disease before and after rotavirus vaccine introduction in the United Kingdom: an observational, seroepidemiological study.

ABSTRACT:

Background

Infant rotavirus vaccination was introduced in the UK in July 2013, and was followed by a rapid reduction in rotavirus disease. We compare immunity to rotavirus in sera of age-stratified cohorts to assess the effect of vaccination on natural exposure to rotavirus.

Methods

Residual serum samples were selected from a reference laboratory biobank based on age, and year of collection. Anti-rotavirus Immunoglobulin G (IgG) and IgA antibodies were measured using ELISA. We used censored linear spline regression models and anti-rotavirus IgA correlate of protection (CoP) thresholds to estimate immunity by age and vaccine eligibility (defined by date of birth).

Results

We analysed serum from 1,200 individuals obtained between 2000 and 2019, of which 807 were vaccine

SUBMITTER: Hungerford D 

PROVIDER: S-EPMC11998831 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature