Development and validation of a harmonized memory score for multicenter Alzheimer's disease and related dementia research.

ABSTRACT:

Introduction

List-learning tasks are important for characterizing memory in ADRD research, but the Uniform Data Set neuropsychological battery (UDS-NB) lacks a list-learning paradigm; thus, sites administer a range of tests. We developed a harmonized memory composite that incorporates UDS memory tests and multiple list-learning tasks.

Methods

Item-banking confirmatory factor analysis was applied to develop a memory composite in a diagnostically heterogenous sample (n=5943) who completed the UDS-NB and one of five list-learning tasks. Construct validity was evaluated through associations with demographics, disease severity, cognitive tasks, brain volume, and plasma phosphorylated tau (p-tau181 and p-tau217). Test-retest reliability was assessed. Analyses were replicated in a

SUBMITTER: Sanderson-Cimino M 

PROVIDER: S-EPMC11998833 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature