Choroid Plexus Enlargement in Secondary Progressive MS: phenotype comparison.

ABSTRACT:

Background

The choroid plexus (CP) is increasingly recognised as a contributor to chronic inflammation in multiple sclerosis (MS). While CP enlargement is reported in early MS, its role in secondary progressive MS (SPMS) is poorly understood.

Objective

We aimed to quantify CP volume in SPMS and compare it to relapsing-remitting MS (RRMS) and clinically isolated syndrome (CIS), and to assess associations with disease severity and progression.

Methods

CP volumes were manually segmented and normalised to intracranial volume. Age correction was applied using a healthy control cohort. Cross-sectional and longitudinal analyses evaluated relationships with ventricular volume, lesion burden, and brain atrophy.

Results

CP volume increased significantly across MS phenoty

SUBMITTER: Klistorner S 

PROVIDER: S-EPMC11998839 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature