Prognostic Features in Surgically Resected Well-Differentiated Pancreatic Neuroendocrine Tumors: An Analysis of 904 Patients with 7882 Person-Years of Follow-Up.

ABSTRACT:

Importance

The clinical behavior of well-differentiated pancreatic neuroendocrine tumors (PanNETs) is difficult to predict.

Objective

To define more accurately prognosticators for patients with a surgically resected PanNET.

Design

The pathology and Ki-67 immunolabeling index of PanNETs resected from 904 patients was correlated with patient outcome.

Setting

Academic tertiary care hospital.

Participants

Consecutive patients who had a PanNET resected between 1985 and 2025.

Results

The mean patient age at surgery was 56.6 years (SD 14.0), 477 were male (52.8%), and 7882 person-years of follow-up were obtained (mean 8.8 years, SD 6.5). The 10-year survival was 81% (95% CI: 77,86%) for patients with G1 PanNETs (Ki-67 <3%), 68% (95% CI: 61,76%) for patie

SUBMITTER: Kiemen AL 

PROVIDER: S-EPMC11998843 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature