Epigenome-wide association study of household air pollution exposure in an area with high lung cancer incidence.

ABSTRACT:

Background

Lung cancer incidence among never-smoking women in Xuanwei, China, ranks among the highest worldwide and is largely attributed to household air pollution (HAP) from smoky (bituminous) coal combustion, with early-life exposures possibly playing a critical role. We conducted an epigenome-wide DNA methylation (DNAm) analysis across multiple exposure windows to elucidate molecular mechanisms.

Methods

Leukocyte DNAm was measured in 106 never-smoking women (23 with repeated measurements). Fuel use was obtained through questionnaires, and extensive personal and environmental monitoring was conducted. Validated exposure models estimated 43 HAP constituents, primarily polycyclic aromatic hydrocarbons (PAHs), across childhood, current, and cumulative exposure windows. Hiera

SUBMITTER: Rahman ML 

PROVIDER: S-EPMC11998846 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature