Large-scale admixture mapping in the <i>All of Us Research Program</i> improves the characterization of cross-population phenotypic differences.

ABSTRACT: Admixed individuals have largely been understudied in medical research due to their complex genetic ancestries. However, the consideration of admixture can help identify ancestry-enriched genetic associations, delineating some of the genetic underpinnings of cross-population phenotypic variation. To this end, we performed local ancestry inference within the All of Us Research Program to identify individuals with recent admixture between African (AFR) and European (EUR) populations (N=48,921). We identified evidence of local AFR ancestry enrichment at the HLA locus, suggestive of putative selection since admixture. Furthermore, we performed the largest admixture mapping (ADM) efforts in AFR-EUR Admixed individuals for 22 traits, identifying 71 associations between inferred local AFR

SUBMITTER: Mandla R 

PROVIDER: S-EPMC11998848 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature