Geospatial and demographic patterns of SARS-CoV-2 spread in Massachusetts from over 130,000 genomes.

ABSTRACT: Despite intensive study, gaps remain in our understanding of SARS-CoV-2 transmission patterns during the COVID-19 pandemic, in part due to limited contextual metadata accompanying most large genomic surveillance datasets. We analyzed over 130,000 SARS-CoV-2 genomes, over 85,000 with matched epidemiological data, collected in Massachusetts from November 2021 to January 2023, to investigate viral transmission dynamics at high resolution. The data were drawn from diagnostic testing at >600 facilities representing schools, workplaces, public testing, and other sectors, and encompass the emergence of six major viral lineages, each representing a new outbreak. We found urban areas as key hubs for new lineage introduction and interurban transmission as facilitating spread throughout the state. Yo

SUBMITTER: Moreno GK 

PROVIDER: S-EPMC11998852 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature