The Pomegranate Flower Water Extract Negatively Regulates Melanogenesis by Suppressing MITF Expression and Its Target Enzymes.

ABSTRACT:

Background

The aesthetic issues caused by pigmentation are increasing people's demand for skin whitening. Considering its long-term use, it is very important for searching safe and effective agents. Pomegranate flower, a kind of traditional Chinese medicine, has shown promising anti-inflammatory, antioxidant, and antidiabetic properties, but its potential skin-lightening effects have not been well explored.

Aims

We investigated the effect of pomegranate flower water extract (PFE) on skin lightening and elucidated its underlying mechanisms.

Methods

The radical scavenging capacity was measured by ABTS and DPPH assays, and the mechanism of lightening was detected by Western blot.

Results

PFE could obviously inhibit tyrosinase activity, which its inhibition IC

SUBMITTER: Shu P 

PROVIDER: S-EPMC11998895 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature