Zebrafish arterial valve development occurs through direct differentiation of second heart field progenitors.

ABSTRACT:

Aims

Bicuspid aortic valve (BAV) is the most common congenital heart defect, affecting at least 2% of the population. The embryonic origins of BAV remain poorly understood, with few assays for validating patient variants, limiting the identification of causative genes for BAV. In both human and mouse, the left and right leaflets of the arterial valves arise from the outflow tract cushions, with interstitial cells originating from neural crest cells and the overlying endocardium through endothelial-to-mesenchymal transition (EndoMT). In contrast, an EndoMT-independent mechanism of direct differentiation of cardiac progenitors from the second heart field (SHF) is responsible for the formation of the anterior and posterior leaflets. Defects in either of these developmental mechanisms

SUBMITTER: Derrick CJ 

PROVIDER: S-EPMC11998914 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature