Bioinformatic identification of COLEC12 as a diagnostic biomarker and risk factor in pediatric FSGS.

ABSTRACT:

Background

In children, focal and segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) have a similar appearance on electron microscopy, making them indistinguishable in clinical diagnosis. Here, we conducted genomic screening to identify a biomarker for the differential diagnosis and assess its clinical implications in pediatric FSGS.

Methods

In the study, cohorts from public databases were analyzed through informatics analysis. First, molecular characteristics were analyzed using Gene Set Enrichment Analysis (GSEA) and Gene Ontology (GO) annotation, and Xcell was used to evaluate the infiltration of immune cells. Next, diagnostic and differentially diagnostic values of candidate biomarkers were studied using Receiver Operating Characteristic (ROC) curve ana

SUBMITTER: Gao L 

PROVIDER: S-EPMC11998918 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature