Inflammation remains a dynamic component of portal hypertension in regressive alcohol-related cirrhosis.

ABSTRACT:

Background

Portal hypertension (PH) resulting from static and dynamic intrahepatic changes drives liver-related complications even after removing the underlying aetiological factor.

Objective

We investigated the impact of inflammation on the dynamic component of PH during disease regression in animal models of toxin-induced cirrhosis and patients with alcohol-related cirrhosis.

Methods

In mice, cirrhosis was induced via toxin application for 12 weeks followed by toxin-withdrawal allowing for one or 2 weeks of regression. Furthermore, 128 patients with alcohol-related cirrhosis and alcohol abstinence undergoing same-day hepatic venous pressure gradient (HVPG) and liver stiffness measurement (LSM) were included. The influence of inflammation on the dynamic PH component

SUBMITTER: Hofer BS 

PROVIDER: S-EPMC11999040 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature