Darvadstrocel for complex perianal fistulas in Crohn's disease: A systematic review and meta-analysis.

ABSTRACT:

Background

Local injection of darvadstrocel, a suspension of expanded adipose-derived allogenic mesenchymal stem cells, has been used for treatment-refractory perianal fistulas in Crohn's disease (CD).

Objective

This study aimed to investigate efficacy and safety of darvadstrocel for complex perianal fistulas in CD.

Methods

A systematic search was conducted through April 2024 in relevant databases for observational studies evaluating darvadstrocel. A random-effects meta-analysis model was used to calculate the pooled effect sizes (proportions or incidence rates [IRs]) with 95% confidence intervals (CIs) of effectiveness and safety outcomes. The risk of bias was evaluated using the Joanna Briggs Institute Critical Appraisal Tool. The I² value assessed hetero

SUBMITTER: Taxonera C 

PROVIDER: S-EPMC11999041 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature