Genetic association studies in critically ill patients: a systematic review.

ABSTRACT:

Background

Critical illness is complex, and genetic research holds the potential to uncover underlying disease mechanisms. However, existing research results have not been systematically summarized. This study aims to compile all genetic association studies in critically ill patients and assess their risks of bias.

Methods

We systematically reviewed PubMed, EMBASE, and the Cochrane Library (PROSPERO protocol: CRD42021209744) and conducted a bias risk assessment of identified studies using a newly developed risk-of-bias assessment tool for genetic association studies. We compiled all significant single nucleotide polymorphisms (SNPs) from the studies identified in our systematic review and conducted a lookup in the results of two genome-wide association studies (GWASs) in cri

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11999069 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature