Incidence of liver complications with hemochromatosis-associated HFE p.C282Y homozygosity: The role of central adiposity.

ABSTRACT:

Background and aims

The HFE p.C282Y+/+ (homozygous) genotype and central adiposity both increase liver disease and diabetes risks, but the combined effects are unclear. We estimated waist-to-hip ratio (WHR) associations with incident clinical outcomes in routine care in p.C282Y+/+ participants in the UK Biobank community cohort.

Approach and results

Baseline WHR data available in 1297 male and 1602 female p.C282Y+/+ with 13.3-year mean follow-up for diagnoses. Spline regressions and Cox proportional hazard models were adjusted for age and genetic principal components. Cumulative incidence was from age 40 to 80 years. In p.C282Y+/+ males, there were positive linear WHR relationships for hospital inpatient-diagnosed liver fibrosis/cirrhosis ( p = 2.4 × 10 -5 ), liver cancer (

SUBMITTER: Lucas MR 

PROVIDER: S-EPMC11999091 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature