Knee and hip osteoarthritis increase the risk of cardiovascular disease: A national registry-based longitudinal cohort study.

ABSTRACT:

Objective

Osteoarthritis and cardiovascular disease are major public health challenges. We aimed to estimate the average sex-specific effects of knee and hip osteoarthritis on the risk of cardiovascular disease.

Methods

We used 2001-2015 Danish national health registry data to identify all adults with knee or hip osteoarthritis and an age-, sex-, and education-matched group without osteoarthritis. Cardiovascular disease outcomes were identified with relevant ICD-10 codes. The effects of osteoarthritis were estimated with sex-stratified multivariable Cox regression models, accounting for multiple sources of confounding determined a priori with a directed acyclic graph. Results were reported with cumulative incidence curves and hazard ratios (HR) conditioned on age, sex, educa

SUBMITTER: Hebert JJ 

PROVIDER: S-EPMC11999113 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature