Computational fluid dynamics of small airway disease in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Small airways (<2 mm diameter) are major sites of airflow obstruction in chronic obstructive pulmonary disease (COPD). This study aimed to quantify the impact of small airway disease, characterized by narrowing, occlusion, and obliteration, on airflow parameters in smokers and end-stage patients with COPDs.

Methods

We performed computational fluid dynamics (CFD) simulations of inspiratory airflow in three lung groups: control non-used donor lungs (no smoking/emphysema history), non-used donor lungs with a smoking history and emphysema, and explanted end-stage COPD lungs. Each group included four lungs, with two tissue cylinders. Micro-CT-scanned small airways were segmented into 3D models for CFD simulations to quantify pressure, resistance, and shear stress. CFD

SUBMITTER: Mohamady YK 

PROVIDER: S-EPMC11999283 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature