Cardiovascular health and its association with dementia, Parkinson's Disease, and mortality among UK older adults.

ABSTRACT:

Background

Previous research has primarily examined individual factors of cardiovascular health (CVH) and disease in PD and dementia, but no study has examined CVH measures with PD, dementia, and mortality simultaneously while accounting for potentially confounding factors.

Objectives

To examine the relationship between CVH, all-cause dementia, Parkinson's disease (PD), and mortality, focusing on associations and health transitions from a large population-based study.

Methods

We investigated these relationships using Cox Proportional Hazards and multistate parametric models with Weibull regression from the UK Biobank data (n = 269,816, Age = 50 + y individuals, ≤15y follow-up, 2006-2021).

Results

Full Cox models found poor CVH (measured with standardized revers

SUBMITTER: Georgescu MF 

PROVIDER: S-EPMC11999287 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature