Dose Constraints in Carbon-Ion Radiation Therapy to Minimize the Risk of Pectoral Myositis.

ABSTRACT:

Purpose

Carbon-ion radiation therapy (C-ion RT) is an emerging nonsurgical treatment for early stage breast cancer, offering biological advantages such as high linear energy transfer (LET) and precise dose distribution. However, the risk of radiation-induced toxicity, particularly pectoral myositis, remains unclear. This study evaluates the relationship between RBE-weighted dose, LET, and pectoral myositis in patients receiving C-ion RT.

Patients and methods

Fourteen patients with cT0-1N0M0 breast cancer were treated with C-ion RT (46-50 Gy [RBE]) in the prone position. Magnetic resonance imaging was performed pretreatment and at 3-month intervals post treatment to assess pectoral myositis. RBE-weighted dose-volume histograms and LET distributions were analyzed. Statistical

SUBMITTER: Okonogi N 

PROVIDER: S-EPMC11999307 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature