Gut flora-derived succinate exacerbates Allergic Airway Inflammation by promoting protein succinylation.

ABSTRACT: Allergic airway inflammation (AAI) is a prevalent respiratory disorder that affects a vast number of individuals globally. There exists a complex interplay among inflammation, immune responses, and metabolic processes, which is of paramount importance in the pathogenesis of AAI. Metabolic dysregulation and protein translational modification (PTM) are well-recognized hallmarks of diseases, playing pivotal roles in the onset and progression of numerous ailments. However, the role of gut microbiota metabolites in the development of AAI, as well as their influence on PTM modifications within this disease context, have not been thoroughly explored and investigated thus far. In AAI patients, succinate was identified as a key metabolite, positively correlated with certain immune parameters and Ig

SUBMITTER: Wang C 

PROVIDER: S-EPMC11999320 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature