Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis.

ABSTRACT:

Background

Novel anticoagulants targeting coagulation factor (F)XI/activated FXI (FXIa) are currently under development. However, whether FXI is present in human deep vein thrombosis (DVT) and whether FXIa and activated FX (FXa) play different roles in venous thrombus formation and hemostasis remain unclear.

Objectives

To determine the presence of FXI in DVT and the effects of direct oral FXIa and FXa inhibitors on venous thrombus formation and hemostasis in rabbits and on in vitro thrombus formation.

Methods

We immunohistochemically assessed FXI localization in human-aspirated DVT (n = 15). Additionally, we compared thrombus formation induced by endothelial denudation and stenosis or stasis in the jugular vein and skin bleeding time and volume between r

SUBMITTER: Oguri N 

PROVIDER: S-EPMC11999338 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature