Copper-coordination driven nano-frameworks for efficient colorectal cancer chemo-immunotherapy by suppression of cancer cell stemness.

ABSTRACT: Cancer stemness, characterized by the self-renewal and differentiation capabilities of cancer stem cells (CSCs), is a critical determinant of colorectal cancer (CRC) chemo-immunotherapy. Herein, we repurposed copper-coordination driven metal-organic nano-frameworks (Cu-MOFs) to address the chemo-immunotherapy resistance posed by cancer stemness. These repurposed Cu-MOFs were loaded with the chemotherapeutic agent cisplatin (CDDP), resulting in the formation of Cu-MOF@CDDP. The Cu-MOF@CDDP are efficiently internalized by CRC cells via nanoparticle mediated endocytosis, where they release free copper ions (Cu²⁺) and CDDP in a high-glutathione (GSH) environment. After that, CDDP forms DNA-CDDP adducts that inhibit DNA synthesis and repair, while Cu²⁺ induces cuproptosis

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11999347 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature