Bioinformatics study and cytotoxicity of several curcumin analogues in ovarian cancer.

ABSTRACT: Ovarian cancer ranks as Indonesia's third-leading cause of cancer-related death, emphasising the need for innovative treatments. This study combined bioinformatics, molecular docking, and experimental assays to tackle this challenge. We identified 166 ovarian cancer-related genes, with MYC standing out as a key target. Analysis of MYC mutations revealed prevalent alterations, though no significant survival differences were observed in patients with or without the mutations. Molecular docking pinpointed compound B155 as a promising MYC inhibitor. A preliminary cytotoxicity assay revealed compound B155's notable activity, with an 87.19 % inhibition of cell viability at 50 μM. Most of the other curcumin analogues only caused more than 50 % inhibition at the same concentration. This result sug

SUBMITTER: Murwanti R 

PROVIDER: S-EPMC11999365 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature