Differential expression of eicosanoid pathways after whole blood stimulation in asthma patients.

ABSTRACT:

Objectives

Asthma is a heterogeneous disease regarding its pathophysiology, clinical symptoms, and response to treatment. Eicosanoids are important inflammatory mediators, able to either promote or attenuate the underlying chronic airway inflammation. We compared eicosanoid expression patterns in the blood circulation and in stimulated blood leukocytes of asthma patients to identify differences in eicosanoid release which may be related to airway inflammation.

Methods

Blood was collected from 198 adult asthmatic patients and 63 healthy controls, participating in the German Center for Lung Research (DZL) ALLIANCE cohort. Eicosanoid release from leukocytes was analyzed using heparinized whole blood after in vitro stimulation with zymosan. Additionally, circulating eicos

SUBMITTER: Skevaki C 

PROVIDER: S-EPMC11999605 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature