Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life.

ABSTRACT: In mammals, spermatogonial cells (SPGs) are undifferentiated male germ cells in testis that are quiescent until birth and then self-renew and differentiate to produce spermatogenic cells and functional sperm from early postnatal life throughout adulthood. The transcriptome of SPGs is highly dynamic and timely regulated during postnatal development. We examined if such dynamics involves changes in chromatin organization by profiling the transcriptome and chromatin accessibility of SPGs from early postnatal stages to adulthood in mice using deep RNA-seq, ATAC-seq and computational deconvolution analyses. By integrating transcriptomic and epigenomic features, we show that SPGs undergo massive chromatin remodeling during postnatal development that partially correlates with distinct gene expres

SUBMITTER: Lazar-Contes I 

PROVIDER: S-EPMC11999699 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature