Ribosomal RNA Biosynthesis Functionally Programs Tumor-Associated Macrophages to Support Breast Cancer Progression.

ABSTRACT: Macrophages are important cellular components of the innate immune system, serving as the first line of immune defense. They are also among the first immune cells to be reprogrammed by the evolving tumor milieu into tumor-supportive macrophages that facilitate tumor progression and promote therapeutic evasion. In this study, we uncovered that macrophages from preneoplastic breast lesions were enriched for ribosome biosynthesis genes, indicating that this is an early event that is maintained in the tumor tissue. Furthermore, following treatment with irradiation or chemotherapy, breast tumors featured an abundance of tumor-supporting macrophages that displayed an enrichment of signatures of rRNA expression and ribosome biosynthesis. Consistently, rRNA synthesis was increased in tumor-support

SUBMITTER: Metge BJ 

PROVIDER: S-EPMC11999771 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature