BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome.

ABSTRACT:

Introduction

Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by pronounced placental oxidative stress and inflammatory damage. However, the contribution of mitophagy to inflammation-induced placental injury in PE remains unclear.

Methods

Human placenta samples were collected from 15 normal pregnant women and 15 preeclampsia pregnant women. Protein expression was analyzed by western blotting, while immunofluorescence staining was employed to localize inflammatory mediators. Mitochondrial reactive oxygen species were quantified using MitoSOX. The concentrations of pro-inflammatory cytokines were quantified using ELISA, and ultrastructural alterations were evaluated by transmission electron microscopy. To investigate molecular mechanisms in vivo, a PE mo

SUBMITTER: Zhao M 

PROVIDER: S-EPMC11999839 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature