Kidney sparing surgery versus radical nephroureterectomy in upper tract urothelial carcinoma: a meta-analysis and systematic review.

ABSTRACT:

Objective

Kidney-sparing surgery (KSS) has been increasingly performed in patients with upper tract urothelial carcinoma (UTUC) in recent years. We aim to conduct a systematic review and meta-analysis comparing the long-term oncologic and renal function outcomes of KSS with those of radical nephroureterectomy (RNU) for UTUC.

Materials and methods

A literature search was conducted on PubMed, Embase, and Web of Science in January 2024. A meta-analysis was performed to analyze overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS), intravesical recurrence-free survival (IVRFS), metastasis-free survival (MFS), and surgery-related estimated glomerular filtration rate (eGFR) variations.

Results

A total of 32 studies with 21615 patients were in

SUBMITTER: Zhou L 

PROVIDER: S-EPMC11999840 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature