<i>BmElmo</i> is a factor for inhibiting <i>Autographa Californica</i> nucleopolyhedrovirus infection in silkworm, <i>Bombyx mori</i>.

ABSTRACT: Autographa californica nucleopolyhedrovirus (AcMNPV) is a DNA virus with multiple host domains, and elucidating the mechanisms of its interactions with silkworms is crucial for its widespread use. Identifying key antiviral genes and analyzing their functions is an urgent task currently. Therefore, the identification and study of host genes associated with AcMNPV invasion is of great significance in solving the issue. Engulfment and cell motility (Elmo) is an identified viral infection-associated gene primarily involved in the regulation of cell motility and essential for phagocytosis and immune responses. However, its function in the silkworm response to viruses is still unclear. In this study, the sequence of BmElmo was analyzed first. It has a CED-12 functional domai

SUBMITTER: Wang ZS 

PROVIDER: S-EPMC11999931 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature