Thyroid function and hepatic fibrosis/cirrhosis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Evidence on the relationship between thyroid function and hepatic fibrosis/cirrhosis are still unclear, with inconsistent conclusions. This Mendelian randomization (MR) study aimed to investigate the potential causal association between thyroid function and hepatic fibrosis/cirrhosis in order to provide new insights for improving prevention and control strategies for this disease.

Methods

Genome-wide association study (GWAS) data on exposures, which included hyperthyroidism, hypothyroidism, and thyroid-stimulating hormone (TSH), were extracted from the MRC Integrative Epidemiology Unit (MRC-IEU) (https://gwas.mrcieu.ac.uk/), and GWAS data for outcomes, including hepatic fibrosis/cirrhosis and chitinase-3-like protein 1 (CHI3L1), were obtained from the FinnGen cons

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11999943 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature