Exploring the role of EBV in multiple sclerosis pathogenesis through EBV interactome.

ABSTRACT:

Background

Epstein-Barr virus (EBV) is a known risk factor for multiple sclerosis (MS), even though the underlying molecular mechanisms are unclear and engage multiple immune pathways. Furthermore, the ultimate role of EBV in MS pathogenesis is still elusive. In contrast, Cytomegalovirus (CMV) has been identified as a protective factor for MS.

Objectives

This study aims to identify MS-associated genes that overlap with EBV interactome and to examine their expression in immune and glial cell subtypes.

Methods

We used P-HIPSTer, GWAS, and the Human Protein Atlas (HPA) to derive data on the EBV interactome, MS-associated genes and single-cell gene expression in immune and glial cells. The geneOverlap and dplyr R packages identified overlapping genes. A similar analysis w

SUBMITTER: Ballerini C 

PROVIDER: S-EPMC11999961 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature