Identification of ferroptosis-related gene signatures in temporal lobe epilepsy with hippocampal sclerosis.

ABSTRACT:

Background

Ferroptosis is a form of regulated cell death that damages neurons in the central nervous system. In this study, we aimed to construct ferroptosis-related gene signatures in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and explore their diagnostic role in TLE-HS.

Methods

The GSE205661 dataset was acquired for training purposes, while the GSE71058 was obtained to serve as the validation dataset. Subsequently, ferroptosis-related differentially expressed genes (FR-DEGs) in TLE-HS were further analyzed. We used weighed gene co-expression network analysis (WGCNA) algorithm, single-factor logistic regression analysis, and LASSO algorithm to screen characteristic FR-DEGs. Then, the receiver operating characteristic (ROC) was used to evaluate the value of t

SUBMITTER: Gao F 

PROVIDER: S-EPMC11999976 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature