Differential immunoregulation by human surfactant protein A variants determines severity of SARS-CoV-2-induced lung disease.

ABSTRACT:

Introduction

COVID-19 remains a significant threat to public health globally. Infection in some susceptible individuals causes life-threatening acute lung injury (ALI/ARDS) and/or death. Human surfactant protein A (SP-A) is a C-type lectin expressed in the lung and other mucosal tissues, and it plays a critical role in host defense against various pathogens. The human SP-A genes (SFTPA1 and SFTPA2) are highly polymorphic and comprise several common genetic variants, i.e., SP-A1 (variants 6A², 6A⁴) and SP-A2 (variants 1A⁰, 1A³). Here, we elucidated the differential antiviral and immunoregulatory roles of SP-A variants in response to SARS-CoV-2 infection in vivo.

Methods

Six genetically-modified mouse lines, expr

SUBMITTER: Jacob IB 

PROVIDER: S-EPMC12000003 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature