Late-midlife lifestyle and brain and cognitive changes in individuals on the AD versus non-AD continuum.

ABSTRACT:

Introduction

We investigated whether a composite measure of late-midlife lifestyle was associated with (1) longitudinal brain changes and (2) cognitive changes when adjusting for these brain changes.

Methods

We used linear mixed models to examine whether the LIfestyle for BRAin Health (LIBRA) index was associated with changes in tau, white matter hyperintensity, neurodegeneration, and cognition and whether changes were similar in amyloid positive (A+; > 17 Centiloids) and negative participants.

Results

We included 324 individuals from the Wisconsin Registry for Alzheimer's Prevention (39% apolipoprotein E [APOE] ε 4 carrier, 30% A+, prior baseline age 67 [50-75]). The LIBRA index was not associated with biomarker trajectories or the primary cognitive composite

SUBMITTER: Oomens JE 

PROVIDER: S-EPMC12000247 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature