Microbiome composition and metabolic pathways in shallow and deep periodontal pockets.

ABSTRACT: In periodontal diseases, a dysbiotic subgingival microbiome interacts complexly with the host immune response and is strongly considered a risk factor for various systemic conditions. The high prevalence of both periodontal and systemic diseases in older adults highlights the importance of characterizing the subgingival microbiome in this age group. This study specifically characterizes the composition of the subgingival microbiome and investigates the interactions between microbial niches in shallow and deep periodontal pockets in individuals in their early 70s. We collected 1928 samples from 1287 participants, all born between 1950 and 1951. Participants had either shallow (≤ 4 mm) periodontal pockets or both shallow and deep (≥ 5 mm) periodontal pockets. Distinct microbial patterns were

SUBMITTER: Moradi J 

PROVIDER: S-EPMC12000285 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature