Validation of a novel CT perfusion software compared to RAPID in stroke patients receiving endovascular therapy.

ABSTRACT: Accurate estimate of ischemic core volume (ICV) and penumbra volume (PV) is important in decision-making for endovascular therapies (EVT) and predicting the patient's clinical outcome. In this study, we compared the performance of a novel automated CT perfusion software UGuard and the Rapid Processing of Perfusion and Diffusion (RAPID). UGuard and RAPID had strong agreement with regard to ICV (ICC 0.92, 95% CI 0.89 - 0.94) and PV (ICC 0.8, 95% CI 0.73 - 0.85) measurements. ICVs measured by UGuard or RAPID were similar in predicting favorable outcome (AUC 0.72 vs. 0.70, P = 0.43), with UGuard measurements having higher specificity. After adjusting for significant clinical covariates, the predictive performance of favorable outcome was excellent for each of the six models incorporating ICV a

SUBMITTER: Chen D 

PROVIDER: S-EPMC12000361 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature