The causal impact of gut microbiota and metabolites on myopia and pathological myopia: a mediation Mendelian randomization study.

ABSTRACT: Myopia, a major cause of irreversible visual impairment globally, is projected to affect about 25% of the world's population by 2025. Myopia progresses through childhood and adolescence, necessitating frequent prescription updates. While genetic and environmental factors are well-established contributors to myopia, emerging evidence suggests a significant role of the gut microbiota (GM) in its development, mainly through metabolic interactions. This study utilized a Mendelian Randomization (MR) approach to investigate the causal relationships between GM, metabolites, and myopia and pathological myopia (PM) progression. Using genetic variants as instrumental variables, we analyzed data from extensive genome-wide association studies (GWAS) to assess the impacts of 473 GM taxa and 233 metabol

SUBMITTER: Hui J 

PROVIDER: S-EPMC12000407 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature