Senescence-induced p21<sup>high</sup> macrophages contributed to CD8<sup>+</sup> T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis.
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ABSTRACT: Recipients' age has emerged as a key factor that impacts on acute renal allograft rejection and graft survival. Age-related functional and structural changes in the immune system have been observed, yet the precise influence of aged immunity on kidney transplant remains unclear. In an initial retrospective analysis of clinical data gathered from two major centers in China and Germany, we found a correlation between aging and mitigated rejection outcomes in kidney recipients. To study the mechanism, we performed kidney transplantation on mice and observed attenuated allograft rejection in senescent recipients. Single-cell transcriptome analysis of allograft kidneys indicated a protective role of p21high macrophages in aged mice. Supernatant collected from p21high macro
SUBMITTER: Zhu T
PROVIDER: S-EPMC12000408 | biostudies-literature | 2025 Apr
REPOSITORIES: biostudies-literature
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