Sporadic detection of vaccine-derived poliovirus type 2 using next-generation sequencing in Canadian wastewater in August of 2022.

ABSTRACT: In July 2022, an unvaccinated young adult living in Rockland County, New York became paralyzed due to a vaccine-derived poliovirus type 2 (VDPV2) infection that was internationally transmitted. Wastewater surveillance in New York State uncovered VDPV2 in neighboring counties, showing silent community spread. These communities have strong epidemiological links to some vaccine-hesitant communities in Canada, spurring the need to monitor these populations for potential poliovirus importation. At the time, Canada did not have an established poliovirus wastewater method. We initiated this study to apply molecular methods to detect poliovirus in these communities and establish poliovirus wastewater surveillance capabilities in Canada. We sequence confirmed one poliovirus detection on August 30th

SUBMITTER: Seo GE 

PROVIDER: S-EPMC12000465 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature