Blood proteome profiling for biomarker discovery in broilers with necrotic enteritis.

ABSTRACT: Analysis of the blood proteome allows identification of proteins related to changes upon certain physiological conditions. The pathophysiology of necrotic enteritis (NE) has been extensively studied. While intestinal changes have been very well documented, data addressing NE-induced alterations in the blood proteome are scant, although these might have merit in diagnostics. In light of recent technological advancements in proteomics and pressing need for tools to access gut health, the current study employs mass-spectrometry (MS)-based proteomics to identify biomarkers for gastrointestinal health of chickens. Here, we report findings of an untargeted proteomics investigation conducted on blood plasma in chickens under NE challenge. Two MS-strategies were used for analysis: conventional dat

SUBMITTER: Tretiak S 

PROVIDER: S-EPMC12000508 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature