The inhibitory effect of Osthole on A549 lung adenocarcinoma cells and its biomarker.

ABSTRACT: Some natural compounds derived from medicinal plants show anti-tumor activity with high efficacy and safety, low toxicity and residual levels etc. The aim of this study was to select natural compounds and biomarkers having high inhibitory effects against A549 adenocarcinoma cells. A total of eight natural compounds having pure plant origin were initially screened, purchased, and their potential anti-cancer activities were comprehensively and systematically evaluated against A549 lung adenocarcinoma cells. The maximum non-cytotoxic concentration (MNTC) and 50% cytotoxic concentration (CC₅₀) of the eight compounds against A549 cells were obtained by cytopathological and MTT assays, respectively. Using Cisplatin as a positive control, the effect of selected compounds were elucidate

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12000571 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature