Curcumin reduces pain after spinal cord injury in rats by decreasing oxidative stress and increasing GABAA receptor and GAD65 levels.

ABSTRACT: About 70% of spinal cord injury (SCI) patients experience neuropathic pain (NP), posing an important medical challenge. Painkillers are used to manage pain today and often have undesirable side effects. Curcumin's antioxidant properties may help alleviate NP following SCI (NP-SCI). We decided to study curcumin's effects on NP-SCI for the first time. Male Wistar rats were divided into five groups (n = 8): Control (no injury/no treatment), Sham (laminectomy), SCI (spinal cord compression at T11-T12 using a clip), Curcumin100 and Curcumin200 (Curcumin at 100 and 200 mg/kg administered 30 min after SCI for 10days). Motor function, allodynia, and hyperalgesia were assessed using the BBB scale, acetone, and tail-flick until six weeks after SCI. H&E staining for assaying cavity, western blot for

SUBMITTER: Hadadi M 

PROVIDER: S-EPMC12000590 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature