Evaluation of urinary metabolites as biomarkers for occupational p-chloronitrobenzene exposure: a pilot study.

ABSTRACT: We explored the feasibility of using urinary metabolites of p-chloronitrobenzene (p-CNB) as exposure biomarkers of occupational p-CNB exposure. Forty-two workers exposed to p-CNB during their jobs at a chemical enterprise in Shaoxing, Zhejiang Province, China were included in the exposure group, while administrative personnel who do not come into contact with p-CNB at work were included in the control group. Each worker in the exposure group was equipped with a personal air sampler to collect airborne p-CNB samples, and urine samples were collected at the conclusion of each shift. After sample collection, the airborne p-CNB concentrations and urinary metabolite concentrations were detected by gas chromatography-tandem mass spectrometry and ultra-performance liquid chromatography - quadrupo

SUBMITTER: Wang P 

PROVIDER: S-EPMC12000600 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature