Galangin exosomes induce cell apoptosis through miR-10b/P53 axis in gastric cancer.

ABSTRACT: Galangin is an extract of traditional Chinese medicine with anti-cancer effect. Exosomes (Exo) contain RNA, peptides, or proteins and communicate between cells through a bio-genesis pathway. In the present study, Gastric cancer (GC) cell exosomes containing galangin were obtained. MicroRNAs (miRNAs) in exosomes containing galangin (galangin-Exo) were screened by RNA-seq. GC cells were treated with galangin-Exo and the changes of cell proliferation were analyzed. Besides, the mouse model of GC was established to verify the effect of galangin-Exo in vivo. The results showed that galangin-Exo inhibited the growth of AGS and BGC823 cells. Additionally, RNA-seq data showed that miR-10b-5p was differentially expressed in exosomes. The reduced expression of miR-10b-5p which increased the expressi

SUBMITTER: Li Q 

PROVIDER: S-EPMC12000617 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature