Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease.

ABSTRACT: Plasma ¹H-NMR metabolomic measures have yielded significant insight into the pathophysiology of cardiometabolic disease, but their inter-related nature complicates causal inference and clinical interpretation. This study aimed to investigate the associations of unrelated ¹H-NMR metabolomic profiles with coronary artery disease (CAD) and ischemic stroke (IS). Principal component (PC) analysis was performed on 168 ¹H-NMR metabolomic measures in 56,712 unrelated European participants from UK Biobank to retrieve uncorrelated PCs, which were used in Cox-proportional hazard models. For each outcome, two-sample Mendelian randomization analyses were then conducted based on three nonoverlapping databases, followed by a meta-analysis. The first six PCs collectively e

SUBMITTER: Ao L 

PROVIDER: S-EPMC12000745 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature