Clinical application of minimal residual disease detection by ctDNA testing in non-small cell lung cancer: a narrative review.

ABSTRACT:

Background and objective

In recent years, significant advancements have been achieved in the treatment of non-small cell lung cancer (NSCLC), leading to prolonged patient survival; however, a subset of NSCLC patients may experience recurrence or distant metastasis following initial successful treatment. This phenomenon may be attributed to the presence of minimal residual disease (MRD) that remains undetectable by conventional imaging or laboratory techniques post-treatment. The potential sources of tumor recurrence (MRD), are significantly associated with adverse patient prognosis; therefore, the monitoring of these lesions is critically important in the management of NSCLC. This review seeks to examine the current evidence regarding the application of MRD in NSCLC clinical practi

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12000943 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature