Persistent and novel changes in plasma microRNA profiles in patients with non-small cell lung cancer following tumour resection.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) accounts for 80% of lung cancers, the leading cause of cancer mortality. microRNAs (miRNA, miR) have emerged as important components of carcinogenesis and promising biomarkers. We aimed to analyse global plasma miRs in NSCLC patients before and at least one year after tumour resection.

Methods

Plasma was collected from the peripheral blood of 24 donors without cancer and of NSCLC patients before surgery (n=36) and at least 1 year after surgery (n=12). Next-generation sequencing (NGS)-based miR profiling was performed. Patients were followed-up for 4 to 12 years after surgery to assess disease recurrence.

Results

Untreated NSCLC patients exhibited significant changes in plasma miR levels compared to cancer-free donors (48 u

SUBMITTER: Sromek M 

PROVIDER: S-EPMC12000959 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature