Cytotoxicity of Pd(ii) and Pt(ii) complexes of 2',6'-di(thiazol-2-yl)-2,4'-bipyridine: insights into the mode of cell death and cell cycle arrest.

ABSTRACT: Square-planar complexes were synthesized by the reaction of 2',6'-di(thiazol-2-yl)-2,4'-bipyridine with either Na₂[PdCl₄] or K₂[PtCl₄], and these were thoroughly structurally characterized using some analytical and spectroscopic techniques. Density functional theory computations, including natural bond orbital analysis, were used to complement the experimental work to gain insight into the natural charge and electronic arrangement of the metal ion, as well as the strength of the metal-ligand bonds. The Pd(ii) complex exhibited exceptional cytotoxicity against the A549 and HCT-116 cell lines with IC₅₀ values of 60.1 ± 3.45 and 23.8 ± 1.48 μM, respectively. Unfortunately, the Pd(ii) complex was harmful to the Vero normal cell line with a

SUBMITTER: Mansour AM 

PROVIDER: S-EPMC12001024 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature