Transcriptomic signatures and network-based methods uncover new senescent cell anti-apoptotic pathways and senolytics.

ABSTRACT: Cellular senescence is an irreversible cell cycle arrest caused by various stressors that damage cells. Over time, senescent cells accumulate and contribute to the progression of multiple age-related degenerative diseases. It is believed that these cells accumulate partly due to their ability to evade programmed cell death through the development and activation of survival and antiapoptotic resistance mechanisms; however, many aspects of how these survival mechanisms develop and activate are still unknown. By analyzing transcriptomic signature profiles generated by the LINCS L1000 project and using network-based methods, we identified various genes that could represent new senescence-related survival mechanisms. Additionally, employing the same methodology, we identified over 600 molecules

SUBMITTER: Olascoaga S 

PROVIDER: S-EPMC12001159 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature