High Concordance between Vaginal Samples and Cervical Samples of Human Papillomavirus in Women Living with HIV in Rwanda.

ABSTRACT:

Background

Chronic infection by human papillomavirus (HPV) is necessary for the development of almost all cervical cancers. The study assessed the prevalence of vaginal and cervical HPV infections in women living with HIV (WLWH) in Rwanda and assessed the performance of vaginal HPV screening to detect cervical HPV infections.

Methods

HIV-positive women (N = 413) attending the HIV clinic at the University Teaching Hospital of Kigali, Kigali, Rwanda, were interviewed and vaginal and cervical swab samples for HPV testing and a pap smear sample were taken. RT-PCR was performed to detect twelve high-risk (HR)-HPVs (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59 and two low-risk (LR)-HPVs (HPV6 and 11) and conventional cytology was performed.

Results

Vaginal HR-HPV/L

SUBMITTER: Uwamungu S 

PROVIDER: S-EPMC12001398 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature