Network pharmacology-based prediction and molecular docking-based strategy to investigate the potential mechanism of Leonurus japonicus Houtt. Against myocardial ischemia reperfusion injury.

ABSTRACT:

Background

Leonurus japonicus Houtt. (LJH) has multiple pharmacological effects.

Objective

To investigate the potential mechanism of LJH in the treatment of myocardial ischemia-reperfusion injury (MIRI) using network pharmacology, molecular docking technology, and in vitro experiments.

Methods

Herbs for ischemic heart disease were identified with the help of herb-disease databases. The TCMSP database was used to find the potential targets of LJH. Disease targets of MIRI were identified with the help of Disgenet, Genecard, Alliance of Genome Resources databases. The common targets were obtained with the help of VENN diagram, and the common targets were analyzed by GO function and KEEG pathway enrichment to predict the potential mechanism of action of LJH in treating MI

SUBMITTER: Liu X 

PROVIDER: S-EPMC12001406 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature